Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 4/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | ALDH1A2 | O94788 | 2/20 | 0.61 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.61 |
| ▸ | ALDH1B1 | P30837 | 2/20 | 0.61 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | GLA | P06280 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | CASP1 | P29466 | 2/20 | 0.58 |
| ▸ | CASP7 | P55210 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10794392 | 0.93 | HSD17B3 (0.68) | HSD17B3ALDH1A1ALDH1A2ALDH2ALDH1B1 | |
| SCHEMBL3767036 | 0.88 | HSD17B3 (1.00) | HSD17B3ALDH1A1ALDH1A2ALDH2ALDH1B1 | |
| SCHEMBL10792079 | 0.88 | HSD17B3 (0.66) | HSD17B3ALDH1A1ALDH1A2ALDH2ALDH1B1 | |
| SCHEMBL10794383 | 0.88 | HSD17B3 (0.61) | HSD17B3ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL10794141 | 0.88 | HSD17B3 (0.65) | HSD17B3ALDH1A1ALDH1A2ALDH2ALDH1B1 | |
| SCHEMBL2786443 | 0.87 | HSD17B3 (0.60) | HSD17B3ALDH1A1ALDH1A2ALDH2ALDH1B1 | |
| SCHEMBL10794476 | 0.85 | HSD17B3 (0.62) | HSD17B3ALDH1A1ALDH1A2ALDH2ALDH1B1 | |
| SCHEMBL10790820 | 0.85 | HSD17B3 (0.62) | HSD17B3ALDH1A1ALDH1A2ALDH2ALDH1B1 | |
| SCHEMBL10790204 | 0.85 | HSD17B3 (0.58) | HSD17B3ALDH1A1ALDH1A2ALDH2ALDH1B1 | |
| SCHEMBL10794998 | 0.84 | HSD17B3 (0.60) | HSD17B3ALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0111746-B1 | SULFONIC-ACID ESTERS OF HYDROXYCOUMARINES, THEIR PREPARATION AND MEDICINES CONTAINING THEM | BASF Aktiengesellschaft (DE) | 1987-09-16 | — | — | EP | disclosed |
| US-4618622-A | ANTIDEPRESSANTS, ANTIALLERGENS | BASF AKTIENGESELLSCHAFT (DE) | 1986-10-21 | — | — | US | disclosed |
| EP-0111746-A2 | Sulfonic-acid esters of hydroxycoumarines, their preparation and medicines containing them | BASF Aktiengesellschaft (DE) | 1984-06-27 | — | — | EP | disclosed |