Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 4/20 | 0.47 |
| ▸ | CA2 | P00918 | 4/20 | 0.47 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | CA3 | P07451 | 2/20 | 0.46 |
| ▸ | CA6 | P23280 | 2/20 | 0.46 |
| ▸ | CA5A | P35218 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.46 |
| ▸ | TYR | P14679 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL27908647 | 0.88 | TSHR (0.63) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL27908648 | 0.88 | TSHR (0.63) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL15167663 | 0.86 | TSHR (0.60) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL21351796 | 0.86 | TSHR (0.60) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL27926667 | 0.84 | TSHR (0.57) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL27926668 | 0.84 | TSHR (0.57) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL15167315 | 0.84 | TSHR (0.57) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL27542194 | 0.84 | TSHR (0.57) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL9123951 | 0.83 | TSHR (0.63) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL27450627 | 0.82 | TSHR (0.55) | TSHRTP53SRD5A2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4675211-A | ONE POLAR SOLVENT | BAYER AKTIENGESELLSCHAFT (DE) | 1987-06-23 | — | — | US | disclosed |