Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.55 |
| ▸ | DRD1 | P21728 | 14/20 | 0.57 |
| ▸ | ADCY5 | O95622 | 2/20 | 0.56 |
| ▸ | DRD2 | P14416 | 8/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | DRD5 | P21918 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.55 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.55 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.55 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.55 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.55 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.55 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.55 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10748725 | 0.92 | ADCY5 (0.56) | DRD1ADCY5DRD2KDM4EDRD5 | |
| SCHEMBL10745927 | 0.91 | ADCY5 (0.57) | DRD1ADCY5DRD2KDM4EDRD5 | |
| SCHEMBL11098639 | 0.90 | ADCY5 (0.68) | DRD1ADCY5DRD2KDM4EDRD5 | |
| Bromide SCHEMBL10345717 | 0.89 | DRD1 (0.73) | DRD1ADCY5DRD2KDM4EDRD5 | |
| Hydrochloric Acid SCHEMBL11096502 | 0.89 | DRD1 (0.68) | DRD1ADCY5DRD2KDM4EDRD5 | |
| SCHEMBL10794597 | 0.88 | DRD1 (0.72) | DRD1ADCY5DRD2KDM4EDRD5 | |
| Bromide SCHEMBL10345904 | 0.87 | DRD1 (0.58) | DRD1ADCY5DRD2KDM4EDRD5 | |
| Bromide SCHEMBL10748869 | 0.85 | ADCY5 (0.58) | DRD1ADCY5DRD2KDM4EDRD5 | |
| Bromide SCHEMBL10345994 | 0.85 | DRD1 (0.73) | DRD1ADCY5DRD2KDM4EDRD5 | |
| SCHEMBL10748842 | 0.84 | ADCY5 (0.59) | DRD1ADCY5DRD2KDM4EDRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4707483-A | 1-phenyl-3-benzazepines and their use for treating gastrointestinal motility disorders | SMITHKLINE BECKMAN CORPORATION (US) | 1987-11-17 | — | — | US | disclosed |