Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 11/20 | 0.55 |
| ▸ | KDR | P35968 | 9/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.55 |
| ▸ | JAK3 | P52333 | 5/20 | 0.55 |
| ▸ | TEK | Q02763 | 3/20 | 0.55 |
| ▸ | BRAF | P15056 | 3/20 | 0.55 |
| ▸ | DDR2 | Q16832 | 4/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | BTK | Q06187 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 3/20 | 0.46 |
| ▸ | RAF1 | P04049 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1077383 | 0.91 | KDR (0.54) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL1077822 | 0.91 | MAPK14 (0.54) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL1149181 | 0.90 | LCK (0.65) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL1077442 | 0.89 | KDR (0.52) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL1082249 | 0.85 | LCK (0.66) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL1149143 | 0.84 | LCK (0.63) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL1079204 | 0.84 | KDR (0.56) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL1076917 | 0.84 | LCK (0.63) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL1148998 | 0.84 | LCK (0.67) | LCKKDRMAPK14JAK3TEK | |
| SCHEMBL1149446 | 0.84 | LCK (0.67) | LCKKDRMAPK14JAK3TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2269993-B1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-02-27 | — | — | EP | disclosed |
| EP-2269993-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | Kyowa Hakko Kirin Co., Ltd. (JP) | 2011-01-05 | — | — | EP | disclosed |