Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.56 |
| ▸ | HTR6 | P50406 | 6/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1046992 | 0.86 | BRD4 (0.50) | BRD4HTR6PIK3C3LMNA | |
| SCHEMBL1046989 | 0.85 | BRD4 (0.49) | BRD4PIK3C3 | |
| SCHEMBL1042704 | 0.84 | BRD4 (0.56) | BRD4HTR6MEN1KMT2AMET | |
| SCHEMBL1050312 | 0.82 | BRD4 (0.64) | BRD4HTR6LMNASMN1; SMN2PTPN11 | |
| SCHEMBL20396921 | 0.80 | BRD4 (0.51) | BRD4PIK3C3PTPN11 | |
| SCHEMBL17939505 | 0.80 | BRD4 (0.52) | BRD4PTPN11 | |
| SCHEMBL1082937 | 0.80 | BRD4 (0.54) | BRD4HTR6PIK3C3PLK1MEN1 | |
| SCHEMBL1887325 | 0.79 | BRD4 (0.58) | BRD4HTR6HTR2AHTR7MET | |
| SCHEMBL1799967 | 0.79 | BRD4 (0.67) | BRD4HTR6PTPN11MET | |
| SCHEMBL1043519 | 0.79 | BRD4 (0.58) | BRD4HTR6MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454257-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | Abbott Laboratories (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011008915-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | WO | disclosed |