SCHEMBL10823908

SCHEMBL10823908

COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(O)[N+](=O)[O-])C1c1ccccc1[N+](=O)[O-]

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 8/20 0.81
ADORA3 P0DMS8 7/20 0.81
CACNA1C Q13936 7/20 0.81
CACNA1F O60840 4/20 0.81
CACNA1D Q01668 4/20 0.81
CACNA1S Q13698 4/20 0.81
LMNA P02545 3/20 0.81
ABCC4 O15439 2/20 0.81
ABCB11 O95342 2/20 0.81
ADORA2A P29274 2/20 0.81
ADORA1 P30542 2/20 0.81
OPRM1 P35372 2/20 0.81
SCN1A P35498 2/20 0.81
HTR2B P41595 2/20 0.81
KCNH2 Q12809 2/20 0.81
SCN5A Q14524 2/20 0.81
SCN2A Q99250 2/20 0.81
SCN3A Q9NY46 2/20 0.81
NR1I2 O75469 1/20 0.81
NR3C1 P04150 1/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10823943 0.93 CACNA1C (0.70) CYP1A2ADORA3CACNA1CCACNA1FCACNA1D
SCHEMBL10823913 0.92 CACNA1D (0.81) CYP1A2ADORA3CACNA1CCACNA1FCACNA1D
SCHEMBL10823958 0.90 CACNA1C (0.69) CYP1A2ADORA3CACNA1CCACNA1FCACNA1D
Nisoldipine SCHEMBL29420725 0.90 CACNA1C (1.00) CYP1A2ADORA3CACNA1CCACNA1FCACNA1D
Nisoldipine SCHEMBL19348996 0.90 CACNA1C (1.00) CYP1A2ADORA3CACNA1CCACNA1FCACNA1D
Nisoldipine SCHEMBL39780 0.90 CACNA1C (1.00) CYP1A2ADORA3CACNA1CCACNA1FCACNA1D
Nisoldipine SCHEMBL1172989 0.90 CACNA1C (1.00) CYP1A2ADORA3CACNA1CCACNA1FCACNA1D
Nisoldipine SCHEMBL39779 0.90 CACNA1C (1.00) CYP1A2ADORA3CACNA1CCACNA1FCACNA1D
Nisoldipine SCHEMBL919020 0.89 CACNA1C (0.98) CYP1A2ADORA3CACNA1CCACNA1FCACNA1D
Nisoldipine SCHEMBL3855961 0.89 CACNA1C (0.98) CYP1A2ADORA3CACNA1CCACNA1FCACNA1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4565824-A Certain nitratoalkyl ester dihydropyridines having antihypertensive properties BAYER AKTIENGESELLSCHAFT (DE) 1986-01-21 US disclosed