Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | PLK1 | P53350 | 5/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ASPH | Q12797 | 1/20 | 0.39 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28278344 | 0.80 | CA12 (0.49) | CA12CA9PLK1CNR1CNR2 | |
| SCHEMBL28310186 | 0.80 | CNR2 (0.50) | CA12CA9PLK1CNR1CNR2 | |
| SCHEMBL28674221 | 0.79 | CLCN2 (0.52) | CA12CA9PLK1CNR1CNR2 | |
| SCHEMBL5136112 | 0.79 | CA12 (0.48) | CA12CA9PLK1CNR1CNR2 | |
| SCHEMBL3478216 | 0.77 | MAPT (0.56) | CA12CA9PLK1HCAR3TSHR | |
| SCHEMBL28859305 | 0.76 | POLB (0.50) | CA12CA9PLK1HCAR3KDM6B | |
| SCHEMBL29402659 | 0.74 | CISD1 (0.57) | CA12CA9PLK1TSHRNAAA | |
| SCHEMBL27485878 | 0.74 | CA12 (0.43) | CA12CA9PLK1CNR1CNR2 | |
| SCHEMBL29400105 | 0.74 | CISD1 (0.57) | CA12CA9PLK1TSHRNAAA | |
| Tetrabuthylammonium SCHEMBL9134628 | 0.73 | TSHR (0.42) | CA12CA9PLK1CNR2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274280-A2 | BIS-ARYL COMPOUNDS FOR USE AS MEDICAMENTS | Biolipox AB (SE) | 2011-01-19 | — | — | EP | disclosed |