Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 16/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.48 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL996695 | 0.83 | PIK3CB (0.56) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL955356 | 0.75 | PIK3CB (0.59) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL477275 | 0.74 | PIK3CB (0.71) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL949619 | 0.73 | PIK3CB (0.66) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL954843 | 0.72 | PIK3CB (0.65) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL995224 | 0.71 | PIK3CA (0.65) | PIK3CBPIK3CAPIK3CDPIK3R1 | |
| SCHEMBL995140 | 0.71 | PIK3CB (0.59) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL477273 | 0.71 | PIK3CA (0.68) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL996060 | 0.71 | PIK3CB (0.60) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL17529072 | 0.69 | PIK3CB (0.55) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451802-A1 | PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES AND THEIR USE IN CANCER THERAPY | Pathway Therapeutics, Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011005119-A1 | PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES AND THEIR USE IN CANCER THERAPY | PATHWAY THERAPEUTICS LIMITED (NZ) | 2011-01-13 | — | — | WO | disclosed |