Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 3/20 | 0.36 |
| ▸ | JAK3 | P52333 | 4/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 5/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | STK17B | O94768 | 1/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 3/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1083487 | 0.85 | TLR7 (0.37) | AKT1RORC | |
| SCHEMBL4365340 | 0.85 | JAK3 (0.39) | ALKJAK3F10EGFRSYK | |
| SCHEMBL13623228 | 0.85 | JAK3 (0.39) | ALKJAK3F10EGFRMET | |
| SCHEMBL13623215 | 0.83 | JAK3 (0.48) | ALKJAK3EGFRJAK2JAK1 | |
| SCHEMBL13623218 | 0.83 | JAK3 (0.51) | JAK3EGFRJAK2 | |
| SCHEMBL1025654 | 0.82 | EGFR (0.42) | ALKJAK3EGFRMETSYK | |
| SCHEMBL13622745 | 0.77 | SYK (0.43) | JAK3EGFRMETSTK17BSTK17A | |
| SCHEMBL1027969 | 0.75 | EGFR (0.43) | JAK3EGFRMETSTK17BSTK17A | |
| SCHEMBL1026903 | 0.75 | STK17B (0.41) | EGFRMETSTK17BSTK17ASYK | |
| SCHEMBL1025626 | 0.75 | SYK (0.42) | JAK3EGFRMETSTK17BSTK17A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |