Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 12/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 12/20 | 1.00 |
| ▸ | ATM | Q13315 | 1/20 | 1.00 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.77 |
| ▸ | NPC1 | O15118 | 1/20 | 0.76 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.75 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.75 |
| ▸ | POLB | P06746 | 1/20 | 0.75 |
| ▸ | GAA | P10253 | 1/20 | 0.75 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | GBA1 | P04062 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16404317 | 0.92 | MEN1 (0.84) | MEN1KMT2AATMRXFP1NPC1 | |
| SCHEMBL1083802 | 0.86 | MEN1 (0.81) | MEN1KMT2AATMRXFP1ALK | |
| SCHEMBL14262975 | 0.85 | MEN1 (0.74) | MEN1KMT2AATMRXFP1NPC1 | |
| SCHEMBL2294947 | 0.83 | ABCG2 (0.76) | MEN1KMT2AATMNPC1GAA | |
| SCHEMBL1064726 | 0.83 | ABCG2 (1.00) | MEN1KMT2AATMGAAABCG2 | |
| SCHEMBL16404494 | 0.83 | ABCG2 (0.95) | MEN1KMT2AATMABCG2MAPT | |
| SCHEMBL16404472 | 0.82 | ABCG2 (0.87) | MEN1KMT2AATMGAAABCG2 | |
| SCHEMBL16404302 | 0.82 | MEN1 (0.69) | MEN1KMT2AATMRXFP1NPC1 | |
| SCHEMBL9937654 | 0.81 | ABCG2 (0.77) | MEN1KMT2AATMNPC1GAA | |
| SCHEMBL16404307 | 0.80 | MEN1 (0.67) | MEN1KMT2AATMRXFP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |