Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.65 |
| ▸ | USP2 | O75604 | 4/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.65 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.65 |
| ▸ | TSHR | P16473 | 3/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.60 |
| ▸ | GBA1 | P04062 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CASP7 | P55210 | 1/20 | 0.59 |
| ▸ | METAP1 | P53582 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3748887 | 0.88 | HTT (0.84) | HTTLMNAALDH1A1CYP1A2USP2 | |
| SCHEMBL4088950 | 0.86 | HTT (0.65) | HTTLMNAALDH1A1CYP1A2USP2 | |
| SCHEMBL1083793 | 0.85 | HTT (0.74) | HTTLMNAALDH1A1CYP1A2USP2 | |
| SCHEMBL13342122 | 0.85 | HTT (0.74) | HTTLMNAALDH1A1CYP1A2USP2 | |
| SCHEMBL1083989 | 0.85 | HTT (0.74) | HTTLMNAALDH1A1CYP1A2USP2 | |
| SCHEMBL1084023 | 0.83 | TP53 (0.74) | HTTLMNAUSP2TSHRTP53 | |
| SCHEMBL4091461 | 0.81 | HTT (0.73) | HTTLMNAALDH1A1CYP1A2USP2 | |
| SCHEMBL8619809 | 0.81 | CYP3A4 (0.76) | HTTLMNAALDH1A1CYP1A2USP2 | |
| SCHEMBL4089879 | 0.81 | MEN1 (0.74) | HTTLMNAALDH1A1CYP1A2USP2 | |
| SCHEMBL4090305 | 0.79 | HTT (0.66) | HTTLMNAALDH1A1CYP1A2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |