Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.38 |
| ▸ | LATS1 | O95835 | 8/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | LATS2 | Q9NRM7 | 7/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1084644 | 0.89 | LATS1 (0.41) | CHEK2LATS1MAPTALKLATS2 | |
| SCHEMBL1084278 | 0.82 | MAPT (0.43) | CHEK2MAPTALKTSHRKMT2A | |
| SCHEMBL1084714 | 0.82 | MAPT (0.40) | CHEK2LATS1MAPTLATS2TSHR | |
| SCHEMBL1084262 | 0.81 | CYP2D6 (0.50) | CHEK2MAPTALKTSHRKMT2A | |
| SCHEMBL1084695 | 0.81 | MAPT (0.46) | CHEK2MAPTTSHRKMT2AMEN1 | |
| SCHEMBL1084781 | 0.81 | MAPT (0.46) | CHEK2MAPTTSHRKMT2AMEN1 | |
| SCHEMBL1084482 | 0.79 | TSHR (0.43) | CHEK2MAPTALKTSHRKMT2A | |
| SCHEMBL1084641 | 0.78 | LATS1 (0.43) | CHEK2LATS1MAPTLATS2TSHR | |
| SCHEMBL1084522 | 0.77 | TSHR (0.43) | CHEK2MAPTALKTSHRKMT2A | |
| SCHEMBL1083973 | 0.77 | MAPT (0.41) | CHEK2LATS1MAPTALKLATS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |