Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 14/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 6/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10845579 | 0.92 | ACE (0.52) | ACEACE2 | |
| SCHEMBL10846942 | 0.86 | ACE (0.58) | ACEACE2 | |
| SCHEMBL10846517 | 0.85 | DPP4 (0.47) | ACEACE2 | |
| SCHEMBL10849422 | 0.83 | ACE (0.58) | ACEACE2 | |
| SCHEMBL10663756 | 0.83 | ACE (0.54) | ACEACE2 | |
| SCHEMBL10847172 | 0.81 | ACE (0.51) | ACEACE2 | |
| SCHEMBL10847513 | 0.80 | ACE (0.60) | ACEACE2 | |
| SCHEMBL10844765 | 0.79 | ACE (0.56) | ACEACE2 | |
| SCHEMBL10836346 | 0.79 | CYP2C19 (0.47) | ACEACE2 | |
| SCHEMBL10847405 | 0.79 | ACE (0.61) | ACEACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4604402-A | HYPOTENSIVE AGNETS | E. R. SQUIBB & SONS, INC. (US) | 1986-08-05 | — | — | US | disclosed |
| EP-0159156-A1 | Hydroxy substituted ureido amino and imino acids | E.R. Squibb & Sons, Inc. (US) | 1985-10-23 | — | — | EP | disclosed |