Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.41 |
| ▸ | SMARCA2 | P51531 | 3/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 3/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 3/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1084753 | 0.97 | MAPT (0.51) | MAPTL3MBTL1HIF1AHTTSMAD3 | |
| SCHEMBL1084253 | 0.92 | MAPT (0.56) | MAPTL3MBTL1HIF1AHTTSMAD3 | |
| SCHEMBL1084670 | 0.90 | MAPT (0.49) | MAPTL3MBTL1HIF1AHTTSMAD3 | |
| SCHEMBL1083878 | 0.90 | MAPT (0.47) | MAPTL3MBTL1HIF1AHTTSMAD3 | |
| SCHEMBL1084230 | 0.89 | MAPT (0.60) | MAPTL3MBTL1HIF1AHTTSMAD3 | |
| SCHEMBL1084417 | 0.89 | MAPT (0.51) | MAPTL3MBTL1HIF1AHTTSMAD3 | |
| SCHEMBL1084113 | 0.88 | MAPT (0.47) | MAPTL3MBTL1HIF1AHTTSMAD3 | |
| SCHEMBL1084083 | 0.88 | GBA1 (0.50) | MAPTL3MBTL1HIF1AHTTSMAD3 | |
| SCHEMBL1084675 | 0.88 | MAPT (0.49) | MAPTL3MBTL1HIF1AHTTSMAD3 | |
| SCHEMBL1084706 | 0.88 | MAPT (0.45) | MAPTL3MBTL1HIF1AHTTSMAD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |