SCHEMBL10845271

SCHEMBL10845271

CC1(C)Oc2cc(N)c([N+](=O)[O-])cc2O1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 1.00
CYP2C9 P11712 1/20 1.00
CYP2C19 P33261 1/20 1.00
MAPT P10636 7/20 0.59
MEN1 O00255 3/20 0.59
POLB P06746 3/20 0.59
KMT2A Q03164 3/20 0.59
MCL1 Q07820 1/20 0.59
L3MBTL1 Q9Y468 1/20 0.59
TSHR P16473 3/20 0.49
TDP1 Q9NUW8 6/20 0.47
ALDH1A1 P00352 5/20 0.47
CYP3A4 P08684 2/20 0.47
ALOX15 P16050 1/20 0.47
MPI P34949 1/20 0.43
PKM P14618 1/20 0.41
LMNA P02545 2/20 0.41
GPR35 Q9HC97 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8313566 0.87 CYP1A2 (0.76) CYP1A2CYP2C9CYP2C19MAPTMEN1
SCHEMBL15554220 0.82 CYP1A2 (0.70) CYP1A2CYP2C9CYP2C19MAPTMEN1
SCHEMBL9687907 0.76 CYP1A2 (0.60) CYP1A2CYP2C9CYP2C19MAPTMEN1
SCHEMBL9686802 0.76 CYP1A2 (0.60) CYP1A2CYP2C9CYP2C19MAPTMEN1
SCHEMBL10845947 0.75 CYP1A2 (0.60) CYP1A2CYP2C9CYP2C19MAPTMEN1
SCHEMBL2887363 0.74 CYP1A2 (0.59) CYP1A2CYP2C9CYP2C19MAPTMEN1
SCHEMBL1624146 0.74 MAPT (1.00) CYP1A2CYP2C9CYP2C19MAPTMEN1
SCHEMBL30581427 0.74 MAPT (1.00) CYP1A2CYP2C9CYP2C19MAPTMEN1
SCHEMBL31000979 0.74 MAPT (1.00) CYP1A2CYP2C9CYP2C19MAPTMEN1
SCHEMBL1625389 0.74 MAPT (1.00) CYP1A2CYP2C9CYP2C19MAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4599347-A ANTIULCER AGENTS HOFFMANN-LA ROCHE INC. (US) 1986-07-08 US disclosed
US-4554280-A ANTISECRETORY AGENTS, ANTIULCER AGENTS HOFFMANN-LA ROCHE INC. (US) 1985-11-19 US disclosed
US-4435406-A 2-PYRIDYL DERIVATIVES OF 1,3-DIOXOLO(4,5-F)BENZIMIDAZOLE RING COMPOUNDS HOFFMANN-LA ROCHE INC. (US) 1984-03-06 US disclosed