Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 12/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13368709 | 0.85 | MAPT (0.59) | MAPTMEN1KMT2AHSP90AA1CHEK2 | |
| SCHEMBL1084777 | 0.83 | MEN1 (0.67) | MEN1KMT2AHSP90AA1CHEK2CHEK1 | |
| SCHEMBL1084806 | 0.82 | MAPT (0.53) | MAPTMEN1KMT2AHSP90AA1CHEK2 | |
| SCHEMBL1084179 | 0.81 | KMT2A (0.55) | MAPTMEN1KMT2AHSP90AA1CHEK2 | |
| SCHEMBL1084783 | 0.81 | MAPT (0.78) | MAPTMEN1KMT2AGAANTRK1 | |
| SCHEMBL1084168 | 0.81 | MEN1 (0.71) | MEN1KMT2AHSP90AA1CHEK2CHEK1 | |
| SCHEMBL1084199 | 0.81 | KMT2A (0.57) | MAPTMEN1KMT2AHSP90AA1GAA | |
| SCHEMBL1084656 | 0.80 | MEN1 (0.48) | MAPTMEN1KMT2AHSP90AA1CHEK2 | |
| SCHEMBL1084416 | 0.80 | MEN1 (0.54) | MAPTMEN1KMT2AHSP90AA1CHEK2 | |
| SCHEMBL1084760 | 0.78 | KMT2A (0.53) | MAPTMEN1KMT2ACHEK2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |