Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.41 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.41 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.41 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.41 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | CASR | P41180 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1084752 | 0.85 | TSHR (0.39) | CLK4PIK3C2BPIK3C2GPIK3CGCLK1 | |
| SCHEMBL1084531 | 0.85 | CLK4 (0.41) | CLK4CLK1CLK2CLK3DYRK1A | |
| SCHEMBL1084073 | 0.83 | GBA1 (0.50) | CLK4CASRTSHRLMNACYP1A2 | |
| SCHEMBL1084261 | 0.83 | PDE5A (0.47) | CLK4CASRTSHRLMNACYP1A2 | |
| SCHEMBL1084574 | 0.82 | MAPT (0.50) | CLK4CLK1CLK2CLK3DYRK1A | |
| SCHEMBL1084534 | 0.82 | PDE5A (0.40) | CLK4CASRTSHRLMNACYP1A2 | |
| SCHEMBL1084219 | 0.81 | GBA1 (0.41) | CLK4CASRTSHRLMNACYP1A2 | |
| SCHEMBL1084529 | 0.80 | TSHR (0.42) | CLK4CASRTSHRLMNACYP1A2 | |
| SCHEMBL1084201 | 0.79 | TSHR (0.44) | CLK4CASRTSHRLMNACYP1A2 | |
| SCHEMBL1084152 | 0.79 | TSHR (0.53) | CLK4CASRTSHRLMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |