Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 17/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.53 |
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1084363 | 0.88 | MEN1 (0.67) | MEN1HSP90AA1KMT2ACHEK2CHEK1 | |
| SCHEMBL1084819 | 0.86 | MEN1 (0.74) | MEN1HSP90AA1KMT2ACHEK2CHEK1 | |
| SCHEMBL1084050 | 0.85 | MEN1 (0.73) | MEN1HSP90AA1KMT2ACHEK2CHEK1 | |
| SCHEMBL1084385 | 0.80 | MEN1 (0.53) | MEN1HSP90AA1KMT2ACHEK2CHEK1 | |
| SCHEMBL1084683 | 0.77 | CHEK2 (0.52) | MEN1HSP90AA1KMT2ACHEK2CHEK1 | |
| SCHEMBL1084118 | 0.77 | GBA1 (0.50) | MEN1HSP90AA1KMT2ACHEK2CHEK1 | |
| SCHEMBL1084679 | 0.77 | MEN1 (0.54) | MEN1HSP90AA1KMT2ACHEK2CHEK1 | |
| SCHEMBL1084656 | 0.77 | MEN1 (0.48) | MEN1HSP90AA1KMT2ACHEK2CHEK1 | |
| SCHEMBL1084266 | 0.77 | MEN1 (0.53) | MEN1HSP90AA1KMT2ACHEK2CHEK1 | |
| SCHEMBL1084676 | 0.75 | MAPT (0.78) | MEN1HSP90AA1KMT2AGBA1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |