Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1084982 | 0.89 | CNR1 (0.48) | MAPTMEN1KMT2AHIF1AL3MBTL1 | |
| SCHEMBL12721403 | 0.87 | CHEK2 (0.41) | MAPTMEN1KMT2AHIF1APIK3CA | |
| SCHEMBL1084495 | 0.86 | KMT2A (0.48) | MAPTMEN1KMT2AHIF1AL3MBTL1 | |
| SCHEMBL937815 | 0.86 | KMT2A (0.43) | MAPTMEN1KMT2AHIF1ANPSR1 | |
| SCHEMBL2603696 | 0.85 | CHEK2 (0.47) | MAPTMEN1KMT2ALMNAHIF1A | |
| SCHEMBL1084639 | 0.85 | MEN1 (0.43) | MAPTMEN1KMT2AHIF1AL3MBTL1 | |
| SCHEMBL12721375 | 0.85 | MAPT (0.45) | MAPTMEN1KMT2ALMNAHIF1A | |
| SCHEMBL183831 | 0.84 | CHEK2 (0.46) | MAPTMEN1KMT2AHIF1AL3MBTL1 | |
| SCHEMBL12721384 | 0.84 | MEN1 (0.42) | MAPTMEN1KMT2AHIF1APIK3CA | |
| SCHEMBL183828 | 0.84 | CHEK2 (0.46) | MAPTMEN1KMT2AHIF1AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |