Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 14/20 | 0.52 |
| ▸ | MEN1 | O00255 | 13/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4519746 | 0.84 | KMT2A (0.52) | KMT2AMEN1RXFP1MAPTHIF1A | |
| SCHEMBL1084297 | 0.83 | KMT2A (0.51) | KMT2AMEN1RXFP1MAPTHIF1A | |
| SCHEMBL1084199 | 0.83 | KMT2A (0.57) | KMT2AMEN1RXFP1MAPTNPSR1 | |
| SCHEMBL1084416 | 0.82 | MEN1 (0.54) | KMT2AMEN1RXFP1MAPTHIF1A | |
| SCHEMBL1084659 | 0.81 | MEN1 (0.51) | KMT2AMEN1RXFP1MAPTHIF1A | |
| SCHEMBL1084215 | 0.80 | PIP4K2C (0.57) | KMT2AMEN1RXFP1MAPTHIF1A | |
| SCHEMBL1084486 | 0.80 | MEN1 (0.54) | KMT2AMEN1RXFP1MAPTHIF1A | |
| SCHEMBL1084888 | 0.80 | KMT2A (0.48) | KMT2AMEN1RXFP1MAPTHIF1A | |
| SCHEMBL13368709 | 0.80 | MAPT (0.59) | KMT2AMEN1RXFP1MAPTHIF1A | |
| SCHEMBL1084806 | 0.79 | MAPT (0.53) | KMT2AMEN1RXFP1MAPTHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |