Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.50 |
| ▸ | GBA1 | P04062 | 3/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1084309 | 0.90 | KMT2A (0.49) | MEN1KMT2ASMAD3MAPTTSHR | |
| SCHEMBL1084547 | 0.85 | MEN1 (0.45) | MEN1KMT2ASMAD3MAPTTSHR | |
| SCHEMBL4066931 | 0.85 | KMT2A (0.48) | MEN1KMT2ASMAD3MAPTTSHR | |
| SCHEMBL14340933 | 0.85 | KMT2A (0.47) | MEN1KMT2ASMAD3MAPTTSHR | |
| SCHEMBL3207639 | 0.83 | GAA (0.43) | MEN1KMT2ASMAD3MAPTTSHR | |
| SCHEMBL1623595 | 0.83 | MEN1 (0.65) | MEN1KMT2ASMAD3MAPTTSHR | |
| SCHEMBL1622796 | 0.83 | MEN1 (0.65) | MEN1KMT2ASMAD3MAPTTSHR | |
| SCHEMBL1622792 | 0.83 | MEN1 (0.65) | MEN1KMT2ASMAD3MAPTTSHR | |
| SCHEMBL1624137 | 0.83 | MAPT (0.58) | MEN1KMT2ASMAD3MAPTTSHR | |
| SCHEMBL12720870 | 0.83 | MEN1 (0.68) | MEN1KMT2ASMAD3MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |