Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.38 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL264969 | 0.83 | SLC6A2 (0.63) | SLC6A2SLC6A3SLC6A4PNMTTAAR1 | |
| SCHEMBL20525350 | 0.82 | IDO1 (0.46) | IDO1DHFRALDH1A1L3MBTL1PNMT | |
| SCHEMBL10729588 | 0.81 | IDO1 (0.56) | IDO1DHFRALDH1A1L3MBTL1FKBP1A | |
| SCHEMBL9386674 | 0.80 | TAAR1 (0.54) | IDO1SLC6A2SLC6A3SLC6A4ALDH1A1 | |
| SCHEMBL21728742 | 0.80 | TAAR1 (0.54) | SLC6A2SLC6A3SLC6A4L3MBTL1TAAR1 | |
| SCHEMBL10187975 | 0.78 | TAAR1 (0.52) | IDO1SLC6A2SLC6A3SLC6A4PYCR1 | |
| SCHEMBL6246687 | 0.78 | TAAR1 (0.52) | SLC6A2SLC6A3SLC6A4L3MBTL1TAAR1 | |
| SCHEMBL4443662 | 0.78 | TAAR1 (0.52) | SLC6A2SLC6A3SLC6A4L3MBTL1TAAR1 | |
| SCHEMBL896162 | 0.78 | SLC6A2 (0.63) | SLC6A2SLC6A3SLC6A4ALDH1A1L3MBTL1 | |
| SCHEMBL44507 | 0.78 | SLC6A2 (0.63) | SLC6A2SLC6A3SLC6A4ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0114374-B1 | SUBSTITUTED 4-AMINOMETHYLENE CHROMANS OR CHROMENES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICINES | BAYER AG (DE) | 1986-07-23 | — | — | EP | disclosed |
| US-4563458-A | CIRCULATORY SYSTEM DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1986-01-07 | — | — | US | disclosed |
| EP-0114374-A1 | Substituted 4-aminomethylene chromans or chromenes, process for their preparation and their use in medicines | BAYER AG (DE) | 1984-08-01 | — | — | EP | disclosed |