Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10854332 | 1.00 | ATM (0.42) | ATMDRD2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL10854338 | 1.00 | ATM (0.42) | ATMDRD2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL10757437 | 0.89 | ATM (0.51) | ATMDRD2ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10757432 | 0.89 | ATM (0.51) | ATMDRD2ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7520297 | 0.89 | ATM (0.42) | ATMDRD2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL10921833 | 0.87 | ATM (0.41) | ATMTAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL10921832 | 0.87 | ATM (0.41) | ATMTAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL7370954 | 0.78 | ATM (0.48) | ATMALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL10759506 | 0.77 | ATM (0.46) | ATMALDH1A1HPGD | |
| SCHEMBL10759500 | 0.77 | ATM (0.46) | ATMALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0088575-B1 | PENTACYCLIC COMPOUNDS | BEECHAM GROUP PLC (GB) | 1986-12-30 | — | — | EP | disclosed |
| US-4585588-A | ANTIDEPRESSANTS | BEECHAM GROUP P.L.C. (GB) | 1986-04-29 | — | — | US | disclosed |
| US-4504480-A | DIAZABENZOCYCLOHEPTAFLUORENE DERIVATRIVES, ANTIDEPRESSANTS | BEECHAM GROUP P.L.C. (GB) | 1985-03-12 | — | — | US | disclosed |