Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM4B | O94953 | 1/20 | 0.36 |
| ▸ | KDM5C | P41229 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10855666 | 0.79 | MAPT (0.44) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19626737 | 0.73 | RECQL (0.44) | KDM4ERECQLTSHRMAPTNPC1 | |
| SCHEMBL10852599 | 0.72 | KDM4E (0.54) | KDM4ERXFP1RECQLMAPTNPC1 | |
| SCHEMBL10857812 | 0.72 | KDM4E (0.47) | KDM4ERXFP1RECQLTSHRMAPT | |
| SCHEMBL27567625 | 0.70 | KDM4E (0.60) | KDM4ERXFP1RECQLTSHRMAPT | |
| SCHEMBL11117023 | 0.69 | GAA (0.42) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10842702 | 0.69 | CYP1A2 (0.40) | KDM4ERECQLSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL10855118 | 0.69 | KDM4E (0.56) | KDM4ERXFP1MAPTSMN1; SMN2HPGD | |
| SCHEMBL11090304 | 0.68 | GSK3B (0.51) | KDM4ETSHRHPGDGSK3BAURKB | |
| SCHEMBL24359598 | 0.67 | GAA (0.52) | KDM4ERECQLTSHRMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4595762-A | 5-α-bromoalkanoyl-2-oxo-3-pyridinecarbonitriles | STERLING DRUG INC. (US) | 1986-06-17 | — | — | US | disclosed |
| US-4539327-A | 5-(2-Substituted-4-thiazolyl)-6-alkyl-2(1H)-pyridinones and cardiotonic use thereof | STERLING DRUG INC. (US) | 1985-09-03 | — | — | US | disclosed |
| US-4469699-A | 5-(4-Thiazolyl)-6-alkyl-2(1H)-pyridinones and their cardiotonic use | STERLING DRUG INC. (US) | 1984-09-04 | — | — | US | disclosed |