Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 2/20 | 0.66 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.66 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SLC47A1 | Q96FL8 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ATP4A | P20648 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ATP4B | P51164 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10854166 | 1.00 | HRH2 (0.66) | HRH2HRH4HRH3L3MBTL1SLC47A1 | |
| SCHEMBL10860304 | 1.00 | HRH2 (0.66) | HRH2HRH4HRH3L3MBTL1SLC47A1 | |
| SCHEMBL10859515 | 0.96 | HRH2 (0.67) | HRH2HRH4HRH3L3MBTL1SLC47A1 | |
| SCHEMBL11154450 | 0.96 | HRH2 (0.62) | HRH2HRH4HRH3L3MBTL1SLC47A1 | |
| Hydrochloric Acid SCHEMBL10856958 | 0.95 | HRH2 (0.66) | HRH2HRH4HRH3L3MBTL1SLC47A1 | |
| Hydrochloric Acid SCHEMBL11167701 | 0.94 | HRH2 (0.61) | HRH2HRH4HRH3L3MBTL1SLC47A1 | |
| SCHEMBL10861202 | 0.94 | HRH2 (0.67) | HRH2HRH4HRH3L3MBTL1SLC47A1 | |
| SCHEMBL9864960 | 0.91 | HRH2 (0.66) | HRH2HRH4HRH3L3MBTL1SLC47A1 | |
| SCHEMBL11558544 | 0.89 | HRH4 (0.57) | HRH2HRH4HRH3 | |
| Hydrochloric Acid SCHEMBL9866856 | 0.89 | HRH2 (0.65) | HRH2HRH4HRH3L3MBTL1SLC47A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4578388-A | HISTAMINE H2-ANTAGONIST; ANTISECRETORY AGENTS | SMITHKLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-03-25 | — | — | US | disclosed |
| US-4405621-A | Heterocyclic thioureas, isothioureas, guanidines and nitromethylene-amidines | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-09-20 | — | — | US | disclosed |
| US-4301165-A | INHIBITORS OF H-2 HISTAMINE RECEPTORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-11-17 | — | — | US | disclosed |
| US-4197305-A | Thiazole, isothiazole, oxazole and isoxazole compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-04-08 | — | — | US | disclosed |
| US-4151289-A | INHIBITORS OF H-2 HISTAMINE RECEPTORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-04-24 | — | — | US | disclosed |
| US-4137319-A | INHIBITORS OF H-2 HISTAMINE RECEPTORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-01-30 | — | — | US | disclosed |
| US-RE29761-E | INHIBITORS OF H-2 HISTAMINE RECEPTORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-09-12 | — | — | US | disclosed |