⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2610826 | 0.78 | — | — | |
| SCHEMBL31675457 | 0.77 | — | — | |
| SCHEMBL19026752 | 0.76 | — | — | |
| SCHEMBL18798826 | 0.74 | — | — | |
| SCHEMBL25464762 | 0.74 | COMT (0.35) | — | |
| SCHEMBL25465243 | 0.74 | COMT (0.35) | — | |
| SCHEMBL23512917 | 0.74 | COMT (0.35) | — | |
| SCHEMBL23489743 | 0.74 | — | — | |
| SCHEMBL25465596 | 0.74 | — | — | |
| SCHEMBL25199078 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12540131-B2 | N-(heteroaryl) quinazolin-2-amine derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof | MERCK SHARP & DOHME LLC (US) | 2026-02-03 | — | — | US | claimed |
| CN-119823045-A | Synthesis method of 3-difluoromethyl-1-methylpyrazole-4-ethyl formate | 湖南化工研究院有限公司 | 2025-04-15 | — | — | CN | claimed |
| US-20230023066-A1 | N-(HETEROARYL) QUINAZOLIN-2-AMINE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | MERCK SHARP & DOHME CORP. (US) | 2023-01-26 | — | — | US | claimed |
| CN-121293156-A | Recovery method of isomer in preparation process of 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-ethyl formate | 河南省氟基新材料科技有限公司 | 2026-01-09 | — | — | CN | disclosed |
| CN-119823045-B | Synthesis method of 3-difluoromethyl-1-methylpyrazole-4-ethyl formate | 湖南化工研究院有限公司 | 2025-10-17 | — | — | CN | disclosed |
| CN-120535463-A | Preparation method of 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-ethyl formate | 多氟多新材料股份有限公司 | 2025-08-26 | — | — | CN | disclosed |
| CN-119823045-A | Synthesis method of 3-difluoromethyl-1-methylpyrazole-4-ethyl formate | 湖南化工研究院有限公司 | 2025-04-15 | — | — | CN | disclosed |
| CN-119823045-A | Synthesis method of 3-difluoromethyl-1-methylpyrazole-4-ethyl formate | 湖南化工研究院有限公司 | 2025-04-15 | — | — | CN | disclosed |
| US-20240390340-A1 | PYRROLIDINE KRAS INHIBITORS | INCYTE CORP (US) | 2024-11-28 | — | — | US | disclosed |
| WO-2024137607-A1 | THIADIAZOLE DERIVATIVES AS INHIBITORS OF CYCLIC GMP-AMP SYNTHASE AND USES THEREOF | VENTUS THERAPEUTICS U.S., INC. (US) | 2024-06-27 | — | — | WO | disclosed |
| CN-112119063-B | Method for producing 3-difluoromethylpyrazole compound, method for producing 3-difluoromethylpyrazole-4-carboxylic acid compound, and pyrazolidine compound | 富士胶片株式会社 | 2023-10-17 | — | — | CN | disclosed |
| US-20140065526-A1 | POSITIVE PHOTOSENSITIVE RESIN COMPOSITION AND METHOD FOR FORMING PATTERNS BY USING THE SAME | CHI MEI CORPORATION (TW) | 2014-03-06 | — | — | US | disclosed |
| US-20140068820-A1 | Pyrazole Compounds for Controlling Invertebrate Pests | BASF SE (DE) | 2014-03-06 | — | — | US | disclosed |
| EP-2164831-B1 | METHOD FOR THE PRODUCTION OF N-SUBSTITUTED (3-DIHALOMETHYL-1-METHYL-PYRAZOLE-4-YL) CARBOXAMIDES | BASF SE (DE) | 2013-07-17 | — | — | EP | disclosed |
| CN-101679282-B | Process for producing N-substituted (3-dihalomethyl-1-methylpyrazol-4-yl) carboxamides | BASF SE | 2012-11-28 | — | — | CN | disclosed |
| US-8153820-B2 | Method for the production of N-substituted (3-dihalomethyl-1-methylpyrazol-4-yl) carboxamides | BASF SE (DE) | 2012-04-10 | — | — | US | disclosed |
| US-20100174094-A1 | Method for the Production of N-Substituted (3-Dihalomethyl-1-Methyl-Pyrazole-4-yl) Carboxamides | BASF SE (DE) | 2010-07-08 | — | — | US | disclosed |
| EP-2164831-A1 | METHOD FOR THE PRODUCTION OF N-SUBSTITUTED (3-DIHALOMETHYL-1-METHYL-PYRAZOLE-4-YL) CARBOXAMIDES | Basf Se (DE) | 2010-03-24 | — | — | EP | disclosed |
| CN-101679282-A | Process for producing N-substituted (3-dihalomethyl-1-methylpyrazol-4-yl) carboxamides | BASF SE | 2010-03-24 | — | — | CN | disclosed |
| WO-2008145740-A1 | METHOD FOR THE PRODUCTION OF N-SUBSTITUTED (3-DIHALOMETHYL-1-METHYL-PYRAZOLE-4-YL) CARBOXAMIDES | BASF SE (DE) | 2008-12-04 | — | — | WO | disclosed |