⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17785732 | 0.86 | — | — | |
| SCHEMBL19403228 | 0.78 | KMT2A (0.36) | — | |
| SCHEMBL12862840 | 0.76 | KMT2A (0.39) | — | |
| SCHEMBL18784935 | 0.76 | — | — | |
| SCHEMBL31041232 | 0.76 | — | — | |
| SCHEMBL18713691 | 0.73 | KMT2A (0.36) | — | |
| SCHEMBL13359788 | 0.73 | KMT2A (0.36) | — | |
| SCHEMBL2629314 | 0.73 | KMT2A (0.36) | — | |
| SCHEMBL9386068 | 0.72 | KDM4C (0.35) | — | |
| SCHEMBL11983586 | 0.70 | SMN1; SMN2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2008996-A1 | Process for the production of pyrazoles | Syngeta Participations AG (CH) | 2008-12-31 | — | — | EP | claimed |
| CN-118852012-A | Synthesis method of high-yield difluoro pyrazole acid | 山东国邦药业有限公司 | 2024-10-29 | — | — | CN | disclosed |
| CN-118515614-A | Synthesis method of difluoro pyrazole acid | 南京大学 | 2024-08-20 | — | — | CN | disclosed |
| CN-114195678-A | Intermediate, preparation method thereof and method for preparing 3-difluoromethyl-1-methylpyrazole-4-ethyl formate by using intermediate | 江苏七洲绿色科技研究院有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-105218448-B | A kind of synthetic method of the pyrazole carboxylic acid of 1 methyl, 3 difluoromethyl 4 | 江苏恒润制药有限公司 | 2017-11-07 | — | — | CN | disclosed |
| CN-106977457-A | A kind of formic acid of 1 methylpyrazole of 3 difluoromethyl 4 and its synthetic method | 浙江海正化工股份有限公司 | 2017-07-25 | — | — | CN | disclosed |
| CN-106467492-A | The preparation method of polyfluoro methyl pyrazoles compound, intermediate and preparation method | 联化科技(盐城)有限公司 | 2017-03-01 | — | — | CN | disclosed |
| CN-102718712-B | Preparation method of 3-difluoro-methyl pyrazole-4-carboxylic acid and 3-trifluoro-methyl pyrazole-4-carboxylic acid | JIANGSU WEIER CHEMICAL CO LTD | 2015-04-29 | — | — | CN | disclosed |
| EP-2164831-B1 | METHOD FOR THE PRODUCTION OF N-SUBSTITUTED (3-DIHALOMETHYL-1-METHYL-PYRAZOLE-4-YL) CARBOXAMIDES | BASF SE (DE) | 2013-07-17 | — | — | EP | disclosed |
| CN-101679282-B | Process for producing N-substituted (3-dihalomethyl-1-methylpyrazol-4-yl) carboxamides | BASF SE | 2012-11-28 | — | — | CN | disclosed |
| US-20100256390-A1 | PROCESSES FOR THE PREPARATION OF PYRAZOLES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-10-07 | — | — | US | disclosed |
| US-20100174094-A1 | Method for the Production of N-Substituted (3-Dihalomethyl-1-Methyl-Pyrazole-4-yl) Carboxamides | BASF SE (DE) | 2010-07-08 | — | — | US | disclosed |
| EP-2170832-A2 | PROCESSES FOR THE PREPARATION OF PYRAZOLES | Syngeta Participations AG (CH) | 2010-04-07 | — | — | EP | disclosed |
| EP-2164831-A1 | METHOD FOR THE PRODUCTION OF N-SUBSTITUTED (3-DIHALOMETHYL-1-METHYL-PYRAZOLE-4-YL) CARBOXAMIDES | Basf Se (DE) | 2010-03-24 | — | — | EP | disclosed |
| CN-101679282-A | Process for producing N-substituted (3-dihalomethyl-1-methylpyrazol-4-yl) carboxamides | BASF SE | 2010-03-24 | — | — | CN | disclosed |
| EP-2008996-A1 | Process for the production of pyrazoles | Syngeta Participations AG (CH) | 2008-12-31 | — | — | EP | disclosed |
| EP-2008996-A1 | Process for the production of pyrazoles | Syngeta Participations AG (CH) | 2008-12-31 | — | — | EP | disclosed |
| WO-2009000442-A2 | PROCESSES FOR THE PREPARATION OF PYRAZOLES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009000442-A2 | PROCESSES FOR THE PREPARATION OF PYRAZOLES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-12-31 | — | — | WO | disclosed |
| WO-2008145740-A1 | METHOD FOR THE PRODUCTION OF N-SUBSTITUTED (3-DIHALOMETHYL-1-METHYL-PYRAZOLE-4-YL) CARBOXAMIDES | BASF SE (DE) | 2008-12-04 | — | — | WO | disclosed |