Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.60 |
| ▸ | HTR1A | P08908 | 4/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 4/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL734110 | 0.80 | HTR2A (0.70) | HTR2AHTR1AHTR6DRD3DRD2 | |
| SCHEMBL10871125 | 0.79 | SMN1; SMN2 (0.51) | HTR2AHTR1ADRD3DRD2MEN1 | |
| SCHEMBL6465788 | 0.78 | HTR2A (0.88) | HTR2AHTR1AHTR6DRD3DRD2 | |
| SCHEMBL10866968 | 0.78 | HTR2A (0.50) | HTR2AHTR1ADRD3DRD2MEN1 | |
| SCHEMBL735143 | 0.76 | HTR2A (0.78) | HTR2AHTR1AHTR6DRD3DRD2 | |
| SCHEMBL25295661 | 0.76 | HTR2A (1.00) | HTR2AHTR1ADRD3DRD2RAB9A | |
| SCHEMBL29543272 | 0.76 | HTR2A (0.94) | HTR2AHTR1ADRD3DRD2RAB9A | |
| SCHEMBL733629 | 0.76 | HTR2A (0.94) | HTR2AHTR1ADRD3DRD2RAB9A | |
| SCHEMBL10872487 | 0.75 | HTR2A (0.63) | HTR2AHTR1AHTR6DRD3DRD2 | |
| SCHEMBL763446 | 0.75 | HTR2A (0.76) | HTR2AHTR1AHTR6DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0187122-A2 | 1,3,4-Trisubstituted azacycloalkanes or azacycloalkenes | CIBA-GEIGY AG (CH) | 1986-07-09 | — | — | EP | disclosed |