Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.60 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 4/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10872487 | 0.82 | HTR2A (0.63) | HTR2AHTR1ADRD3DRD2SLC6A4 | |
| SCHEMBL6465788 | 0.78 | HTR2A (0.88) | HTR2AHTR1ADRD3DRD2BCHE | |
| SCHEMBL10873341 | 0.78 | HTR2A (0.54) | HTR2AHTR1ADRD3DRD2SLC6A4 | |
| SCHEMBL10869866 | 0.76 | HTR2A (0.51) | HTR2AHTR1ADRD3DRD2SLC6A4 | |
| SCHEMBL25295661 | 0.76 | HTR2A (1.00) | HTR2AHTR1ADRD3DRD2BCHE | |
| SCHEMBL733629 | 0.76 | HTR2A (0.94) | HTR2AHTR1ADRD3DRD2BCHE | |
| SCHEMBL29543272 | 0.76 | HTR2A (0.94) | HTR2AHTR1ADRD3DRD2BCHE | |
| SCHEMBL13684158 | 0.76 | HTR2A (0.68) | HTR2AHTR1ADRD3DRD2SLC6A4 | |
| Hydrochloric Acid SCHEMBL10870609 | 0.75 | HTR2A (0.50) | HTR2AHTR1ADRD3DRD2SLC6A4 | |
| SCHEMBL734226 | 0.74 | HTR2A (0.91) | HTR2AHTR1ADRD3DRD2BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0187619-A2 | 1,3-Disubstituted tetrahydropyridines | CIBA-GEIGY AG (CH) | 1986-07-16 | — | — | EP | disclosed |
| EP-0187122-A2 | 1,3,4-Trisubstituted azacycloalkanes or azacycloalkenes | CIBA-GEIGY AG (CH) | 1986-07-09 | — | — | EP | disclosed |