SCHEMBL10873397

SCHEMBL10873397

O=[N+]([O-])C=C1NCCCN1Cc1ccc(C(F)(F)F)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA1 P02708 1/20 0.65
CHRNA3 P32297 1/20 0.65
CHRNA7 P36544 1/20 0.65
SMN1; SMN2 Q16637 3/20 0.57
ALDH1A1 P00352 3/20 0.42
KDM4E B2RXH2 1/20 0.42
CHRNB2 P17787 1/20 0.36
CHRNA4 P43681 1/20 0.36
FBP1 P09467 1/20 0.36
HIF1A Q16665 2/20 0.36
EPAS1 Q99814 2/20 0.36
POLB P06746 1/20 0.35
CHKA P35790 1/20 0.35
TGM2 P21980 1/20 0.35
HDAC1 Q13547 1/20 0.35
TEAD1 P28347 2/20 0.34
HRH3 Q9Y5N1 1/20 0.34
HTR2C P28335 1/20 0.34
HTR2B P41595 1/20 0.34
HCRTR2 O43614 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28132723 0.94 SMN1; SMN2 (0.63) CHRNA1CHRNA3CHRNA7SMN1; SMN2ALDH1A1
SCHEMBL28392880 0.88 CHRNA1 (0.65) CHRNA1CHRNA3CHRNA7SMN1; SMN2ALDH1A1
Pyridine SCHEMBL28145143 0.87 SMN1; SMN2 (0.59) CHRNA1CHRNA3CHRNA7SMN1; SMN2ALDH1A1
SCHEMBL9408586 0.86 CHRNA1 (0.69) CHRNA1CHRNA3CHRNA7SMN1; SMN2ALDH1A1
SCHEMBL10873855 0.86 CHRNA1 (0.69) CHRNA1CHRNA3CHRNA7SMN1; SMN2ALDH1A1
SCHEMBL7993656 0.85 CHRNA1 (0.71) CHRNA1CHRNA3CHRNA7SMN1; SMN2ALDH1A1
SCHEMBL9408699 0.85 CHRNA1 (0.74) CHRNA1CHRNA3CHRNA7SMN1; SMN2ALDH1A1
SCHEMBL10684318 0.85 CHRNA1 (0.74) CHRNA1CHRNA3CHRNA7SMN1; SMN2ALDH1A1
SCHEMBL10876966 0.84 CHRNA1 (0.69) CHRNA1CHRNA3CHRNA7SMN1; SMN2ALDH1A1
SCHEMBL9408573 0.84 CHRNA1 (0.69) CHRNA1CHRNA3CHRNA7SMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0199974-A2 Nitromethylene-tetrahydropyrimidine NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1986-11-05 EP claimed
JP-61227571-A None JP disclosed
EP-0199974-A2 Nitromethylene-tetrahydropyrimidine NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1986-11-05 EP disclosed
JP-S61227571-A NITROMETHYLENE-TETRAHYDROPYRIMIDINE DERIVATIVE, PRODUCTION THEREOF AND INSECTICIDE NIPPON TOKUSHU NOYAKU SEIZO KK 1986-10-09 JP disclosed