Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10877562 | 0.94 | SCN5A (0.42) | TDP1MAPK1CYP3A4TSHRALDH1A1 | |
| SCHEMBL10880336 | 0.90 | TDP1 (0.44) | TDP1MAPK1CYP3A4TSHRALDH1A1 | |
| SCHEMBL10705437 | 0.86 | TDP1 (0.41) | TDP1MAPK1CYP3A4TSHRALDH1A1 | |
| SCHEMBL10889260 | 0.83 | TSHR (0.54) | TDP1MAPK1CYP3A4TSHRALDH1A1 | |
| SCHEMBL16681878 | 0.82 | TDP1 (0.38) | TDP1MAPK1CYP3A4TSHRALDH1A1 | |
| SCHEMBL10455911 | 0.81 | TDP1 (0.44) | TDP1MAPK1CYP3A4TSHRALDH1A1 | |
| Alcohol SCHEMBL10456917 | 0.78 | TDP1 (0.42) | TDP1MAPK1CYP3A4TSHRALDH1A1 | |
| SCHEMBL3120739 | 0.77 | MEN1 (0.35) | TDP1MAPK1CYP3A4TSHRALDH1A1 | |
| SCHEMBL21340375 | 0.77 | TDP1 (0.41) | TDP1MAPK1CYP3A4TSHRALDH1A1 | |
| SCHEMBL1423791 | 0.76 | CNR2 (0.37) | CYP3A4ALDH1A1KMT2AMEN1CASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049913-B1 | NEW ETHENYLIMIDAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM; INTERMEDIATES, USEFUL IN THEIR PREPARATION AND A PROCESS FOR THE PREPARATION THEREOF | GIST-BROCADES N.V. (NL) | 1986-03-19 | — | — | EP | disclosed |
| US-4414210-A | 2-Hydroxyarylethyltriazole fungicides | ROHM AND HAAS COMPANY (US) | 1983-11-08 | — | — | US | disclosed |
| US-4413003-A | FUNGICIDES | ROHM AND HAAS COMPANY (US) | 1983-11-01 | — | — | US | disclosed |
| EP-0049913-A2 | New ethenylimidazole derivatives, processes for their preparation and pharmaceutical compositions containing them; intermediates, useful in their preparation and a process for the preparation thereof | GIST-BROCADES N.V. (NL) | 1982-04-21 | — | — | EP | disclosed |