Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10877780 | 0.84 | TSHR (0.49) | TSHRMAPK1HSD17B10KDM4EHTT | |
| SCHEMBL10876854 | 0.84 | MAPT (0.74) | TSHRMAPK1HSD17B10KDM4EHTT | |
| SCHEMBL10666086 | 0.80 | TSHR (0.67) | TSHRMAPK1HSD17B10KDM4EHTT | |
| SCHEMBL10666106 | 0.76 | TSHR (0.66) | TSHRMAPK1HSD17B10KDM4EHTT | |
| SCHEMBL10666220 | 0.75 | TSHR (0.60) | TSHRMAPK1HSD17B10KDM4EHTT | |
| SCHEMBL10667875 | 0.74 | TSHR (0.62) | TSHRMAPK1HSD17B10KDM4EHTT | |
| SCHEMBL2885346 | 0.74 | MAPT (0.77) | TSHRMAPK1HSD17B10KDM4EHTT | |
| SCHEMBL7608266 | 0.73 | KDM4E (0.68) | TSHRMAPK1HSD17B10KDM4EHTT | |
| SCHEMBL2886423 | 0.71 | MAPT (1.00) | TSHRMAPK1HSD17B10MAPTRXFP1 | |
| SCHEMBL10667650 | 0.70 | TSHR (0.53) | TSHRMAPK1HSD17B10KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0085840-B1 | NEW 6-SUBSTITUTED-S-TRIAZOLO(3,4-A)PHTHALAZINE DERIVATIVES | GRUPPO LEPETIT S.P.A. (IT) | 1986-10-01 | — | — | EP | disclosed |