Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | METAP2 | P50579 | 8/20 | 0.38 |
| ▸ | METAP1 | P53582 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | CPA1 | P15085 | 1/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27869893 | 1.00 | MGAM (0.41) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL10882828 | 1.00 | MGAM (0.41) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL10970199 | 1.00 | MGAM (0.41) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL11185813 | 0.91 | MGAM (0.48) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL805116 | 0.82 | MGAM (0.44) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL4680662 | 0.82 | MGAM (0.44) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL10204950 | 0.82 | MGAM (0.44) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL804999 | 0.79 | — | — | |
| SCHEMBL864303 | 0.79 | — | — | |
| SCHEMBL805100 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0061768-B1 | N-AMIDO SUBSTITUTED DIPEPTIDES | USV PHARMACEUTICAL CORPORATION (US) | 1986-05-14 | — | — | EP | disclosed |
| US-4558038-A | HYPOTENSIVE AGENTS | USV PHARMACEUTICAL CORP. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4496542-A | HYPOTENSIVE AGENTS; ENZYME INHIBITORS | USV PHARMACEUTICAL CORPORATION (US) | 1985-01-29 | — | — | US | disclosed |
| EP-0061768-A1 | N-amido substituted dipeptides | USV PHARMACEUTICAL CORPORATION (US) | 1982-10-06 | — | — | EP | disclosed |