Cholesterol

SCHEMBL10883099

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C.CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C.CCCCCCCCCCCCCCCCCC(=O)O

nearest known ligand 0.79

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Cholesterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	OSBP	P22059	3/20	0.79

▸	RORC	P51449	2/20	0.79

▸	USP2	O75604	1/20	0.79

▸	LMNA	P02545	1/20	0.79

▸	ABCB1	P08183	1/20	0.79

▸	OSBP2	Q969R2	1/20	0.79

▸	CYP46A1	Q9Y6A2	1/20	0.79

▸	NR1H3	Q13133	6/20	0.77

▸	EPHA2	P29317	1/20	0.77

▸	GRIN1	Q05586	1/20	0.68

▸	GRIN2A	Q12879	1/20	0.68

▸	NPC1L1	Q9UHC9	2/20	0.67

▸	POLA1	P09884	1/20	0.67

▸	DHCR24	Q15392	1/20	0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Cholesterol SCHEMBL970382	1.00	OSBP (0.79)	OSBPRORCUSP2LMNAABCB1
Cholesterol SCHEMBL9566174	1.00	OSBP (0.79)	OSBPRORCUSP2LMNAABCB1
Cholesterol SCHEMBL7736671	1.00	OSBP (0.79)	OSBPRORCUSP2LMNAABCB1
Cholesterol SCHEMBL161748	1.00	OSBP (0.79)	OSBPRORCUSP2LMNAABCB1
Cholesterol SCHEMBL2195602	1.00	OSBP (0.79)	OSBPRORCUSP2LMNAABCB1
Cholesterol SCHEMBL10933840	1.00	OSBP (0.79)	OSBPRORCUSP2LMNAABCB1
Cholesterol SCHEMBL25174230	1.00	OSBP (0.79)	OSBPRORCUSP2LMNAABCB1
Cholesterol SCHEMBL16415838	1.00	OSBP (0.79)	OSBPRORCUSP2LMNAABCB1
Cholesterol SCHEMBL22749559	1.00	OSBP (0.79)	OSBPRORCUSP2LMNAABCB1
Cholesterol SCHEMBL892123	1.00	OSBP (0.79)	OSBPRORCUSP2LMNAABCB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0084898-B1	LIPOSOME AND SODIUM CROMOGLYCATE COMPOSITIONS, AND METHODS FOR THEIR PREPARATION	FISONS plc (GB)	1986-09-03	—	—	EP	claimed
US-4028282-A	SLURRY OF OLEFIN SULFONATE, SODIUM SILICATE, SODIUM CARBONATE, WATER	LION FAT & OIL CO., LTD. (JA)	1977-06-07	—	—	US	disclosed
US-3948818-A	A SALT OF A BASIC AMINO ACID OF AN ORGANIC SULFONIC ACID OR ESTER SULFATE AS SURFACTANT	LION FAT & OIL CO., LTD. (JA)	1976-04-06	—	—	US	disclosed