Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 2/20 | 0.55 |
| ▸ | SPHK1 | Q9NYA1 | 14/20 | 0.53 |
| ▸ | SPHK2 | Q9NRA0 | 7/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10883240 | 1.00 | ESR2 (0.55) | ESR2SPHK1SPHK2ALOX5 | |
| SCHEMBL14030486 | 0.95 | ESR2 (0.50) | ESR2SPHK1SPHK2 | |
| SCHEMBL6746557 | 0.95 | ESR2 (0.50) | ESR2SPHK1SPHK2ALOX5 | |
| SCHEMBL4323763 | 0.90 | SPHK1 (0.61) | SPHK1SPHK2 | |
| SCHEMBL11828165 | 0.89 | SPHK1 (0.62) | ESR2SPHK1SPHK2 | |
| SCHEMBL19712025 | 0.88 | SPHK1 (0.69) | ESR2SPHK1SPHK2 | |
| SCHEMBL11041570 | 0.86 | SPHK1 (0.72) | SPHK1SPHK2 | |
| SCHEMBL11039849 | 0.86 | SPHK1 (0.72) | SPHK1SPHK2 | |
| SCHEMBL10453965 | 0.86 | SPHK1 (0.72) | SPHK1SPHK2 | |
| SCHEMBL11039846 | 0.86 | SPHK1 (0.72) | SPHK1SPHK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0103681-B1 | TETRA- AND PENTACYCLIC MONOESTERS | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1986-07-30 | — | — | EP | disclosed |
| US-4526704-A | Esters containing phenylene and cyclohexylene rings | HOFFMANN-LA ROCHE INC. (US) | 1985-07-02 | — | — | US | disclosed |
| US-4487954-A | LIQUID CRYSTALS | CHISSO CORPORATION (JP) | 1984-12-11 | — | — | US | disclosed |
| EP-0103681-A1 | Tetra- and pentacyclic monoesters | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-03-28 | — | — | EP | disclosed |