SCHEMBL10885263

SCHEMBL10885263

FCC(Cl)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.50
TAAR1 Q96RJ0 3/20 0.40
HTR2A P28223 2/20 0.40
DPP4 P27487 2/20 0.38
F2 P00734 1/20 0.38
HRH1 P35367 2/20 0.37
MTOR P42345 1/20 0.37
RAB9A P51151 1/20 0.37
GRM7 Q14831 1/20 0.37
LMNA P02545 1/20 0.36
CYP3A4 P08684 1/20 0.36
ALOX15 P16050 1/20 0.36
KDM4E B2RXH2 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
TDP1 Q9NUW8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9425022 0.78 TSHR (0.55) TSHRTAAR1HTR2ADPP4F2
SCHEMBL22042229 0.78 TSHR (0.55) TSHRTAAR1HTR2ADPP4F2
SCHEMBL13639028 0.77 HTR2A (0.43) TSHRTAAR1HTR2AHRH1CYP3A4
SCHEMBL138020 0.76 TSHR (0.52) TSHRTAAR1HTR2ADPP4F2
SCHEMBL4770684 0.75 HRH1 (0.42) TSHRTAAR1HTR2AHRH1
SCHEMBL1146364 0.74 TSHR (0.50) TSHRTAAR1HTR2ADPP4F2
SCHEMBL21753497 0.74 TSHR (0.50) TSHRTAAR1HTR2ADPP4F2
SCHEMBL22042223 0.74 TSHR (0.50) TSHRTAAR1HTR2ADPP4F2
SCHEMBL3406287 0.74 TAAR1 (0.59) TSHRTAAR1HTR2ADPP4F2
SCHEMBL8609744 0.74 TSHR (0.50) TSHRTAAR1HTR2ADPP4F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0009787-B2 PROCESS FOR THE MONOHALOGENATION OF ALKYLBENZENES IN ALPHA POSITION BAYER AG (DE) 1986-07-09 EP disclosed
US-4331821-A ULTRAVIOLET RADIATION OF A VAPORIZED ALKYLBENZEN AND HALOGEN GAS MIXTURE BAYER AKTIENGESELLSCHAFT (DE) 1982-05-25 US disclosed
EP-0009787-B1 PROCESS FOR THE MONOHALOGENATION OF ALKYLBENZENES IN ALPHA POSITION BAYER AG (DE) 1982-01-13 EP disclosed
EP-0009787-A2 Process for the monohalogenation of alkylbenzenes in alpha position BAYER AG (DE) 1980-04-16 EP disclosed