SCHEMBL10885268

SCHEMBL10885268

COc1cc(C)nc(NC(=O)NS(=O)(=O)c2ccccc2O)n1

nearest known ligand 0.64

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.54
SMN1; SMN2 Q16637 2/20 0.52
TSHR P16473 2/20 0.52
CDK1 P06493 1/20 0.48
HTT P42858 1/20 0.46
TP53 P04637 1/20 0.44
GLA P06280 1/20 0.44
MAPT P10636 1/20 0.44
KDM4E B2RXH2 1/20 0.41
NPC1 O15118 1/20 0.41
ALDH1A1 P00352 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10884559 0.93 GAA (0.61) GAACDK1TP53GLAMAPT
SCHEMBL10672734 0.90 GAA (0.53) GAASMN1; SMN2TSHRCDK1HTT
SCHEMBL11560856 0.90 GAA (0.55) GAASMN1; SMN2TSHRCDK1HTT
SCHEMBL9805001 0.89 GAA (0.49) GAATSHRMAPTKDM4ENPC1
SCHEMBL11265505 0.88 KDM4E (0.55) GAASMN1; SMN2TSHRCDK1KDM4E
SCHEMBL10733365 0.88 GAA (0.53) GAASMN1; SMN2TSHRCDK1HTT
SCHEMBL10389119 0.88 GAA (0.53) GAASMN1; SMN2TSHRCDK1HTT
SCHEMBL10506007 0.87 TSHR (0.53) GAASMN1; SMN2TSHRCDK1HTT
Hydrochloric Acid SCHEMBL11113105 0.87 GAA (0.52) GAASMN1; SMN2TSHRCDK1HTT
SCHEMBL11454190 0.87 GAA (0.55) GAASMN1; SMN2TSHRCDK1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0044212-B1 HERBICIDAL O-ALKYLSULFONYLOXY- AND O-ALKYLSULFONYLAMINO-BENZENESULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1985-04-10 EP claimed
US-4435205-A Herbicidal o-alkylsulfonyloxy- and o-alkylsulfonylaminobenzenesulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1984-03-06 US claimed
EP-0044212-A1 Herbicidal o-alkylsulfonyloxy- and o-alkylsulfonylamino-benzenesulfonamides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1982-01-20 EP claimed
US-4629496-A Herbicidal O-alkylsulfonyloxy- and O-alkylsulfonylaminobenzenesulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1986-12-16 US disclosed
US-4534789-A PREEMERGENCE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-08-13 US disclosed
EP-0044212-B1 HERBICIDAL O-ALKYLSULFONYLOXY- AND O-ALKYLSULFONYLAMINO-BENZENESULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1985-04-10 EP disclosed
US-4435205-A Herbicidal o-alkylsulfonyloxy- and o-alkylsulfonylaminobenzenesulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1984-03-06 US disclosed
EP-0044212-A1 Herbicidal o-alkylsulfonyloxy- and o-alkylsulfonylamino-benzenesulfonamides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1982-01-20 EP disclosed