Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 9/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.61 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.61 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.47 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.47 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10886965 | 0.84 | KDM4E (0.64) | MCL1KDM4EALDH1A1HPGDPIK3CD | |
| SCHEMBL10889950 | 0.82 | MCL1 (0.60) | MCL1KDM4EALDH1A1HPGDPIK3CD | |
| SCHEMBL8305565 | 0.80 | MCL1 (1.00) | MCL1KDM4EALDH1A1HPGDPIK3CD | |
| SCHEMBL11167009 | 0.80 | MCL1 (0.73) | MCL1KDM4EALDH1A1HPGDPIK3CD | |
| SCHEMBL10892490 | 0.80 | MCL1 (0.73) | MCL1KDM4EALDH1A1HPGDPIK3CD | |
| SCHEMBL10891641 | 0.80 | MCL1 (0.73) | MCL1KDM4EALDH1A1HPGDPIK3CD | |
| SCHEMBL11168852 | 0.80 | MCL1 (0.73) | MCL1KDM4EALDH1A1HPGDPIK3CD | |
| SCHEMBL10887196 | 0.79 | MCL1 (0.56) | MCL1KDM4EALDH1A1HPGDPIK3CD | |
| SCHEMBL5397726 | 0.79 | MCL1 (1.00) | MCL1KDM4EALDH1A1HPGDPIK3CD | |
| SCHEMBL7281879 | 0.76 | PIK3CD (1.00) | MCL1KDM4EALDH1A1HPGDPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4599423-A | Preparation of 5-(hydroxy- and/or aminophenyl-6-lower-alkyl)-2(1H)-pyridinones | STERLING DRUG INC. (US) | 1986-07-08 | — | — | US | disclosed |
| US-4559352-A | 1,2-Dihydro-2-oxo-5-(hydroxy-and/or amino-phenyl)-nicotinonitriles and cardiotonic use thereof | STERLING DRUG INC. (US) | 1985-12-17 | — | — | US | disclosed |
| US-4515797-A | 3-Amino-5-(hydroxy- and/or aminophenyl)-6-(lower-alkyl)-2(1H)-pyridinones and cardiotonic use thereof | STERLING DRUG INC. (US) | 1985-05-07 | — | — | US | disclosed |
| US-4465686-A | 5-(Hydroxy- and/or amino-phenyl)-6-(lower-alkyl)-2-(1H)-pyridinones, their cardiotonic use and preparation | STERLING DRUG INC. (US) | 1984-08-14 | — | — | US | disclosed |
| EP-0074091-A2 | 2(1H)-pyridinones and preparation thereof | STERLING DRUG INC. (US) | 1983-03-16 | — | — | EP | disclosed |
| EP-0061774-A2 | 3-Amino-5-(substituted)-2 (1H) pyridinones and 3-cyano compounds useful as cardiotonics and preparation thereof | STERLING DRUG INC. (US) | 1982-10-06 | — | — | EP | disclosed |