Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.75 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | MPI | P34949 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12364566 | 0.98 | MAPT (0.72) | MAPTKDM4ELMNAPKMMPI | |
| SCHEMBL12201136 | 0.84 | KDM4E (0.79) | MAPTKDM4ELMNAPKMMPI | |
| SCHEMBL8009677 | 0.84 | MAPT (0.61) | MAPTKDM4ELMNAPKMMPI | |
| SCHEMBL8943203 | 0.84 | MAPT (0.96) | MAPTKDM4ELMNAPKMMPI | |
| Iodide SCHEMBL10888241 | 0.83 | KDM4E (0.94) | MAPTKDM4ELMNAPKMMPI | |
| Iodide SCHEMBL4012476 | 0.83 | MAPT (0.57) | MAPTKDM4ELMNAPKMMPI | |
| Iodide SCHEMBL4013272 | 0.83 | MAPT (0.57) | MAPTKDM4ELMNAPKMMPI | |
| Iodide SCHEMBL18166876 | 0.83 | MAPT (0.57) | MAPTKDM4ELMNAPKMMPI | |
| SCHEMBL1048707 | 0.81 | MAPT (0.54) | MAPTKDM4ELMNAPKMMPI | |
| SCHEMBL18416406 | 0.81 | MAPT (0.54) | MAPTKDM4ELMNAPKMMPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0103294-B1 | N-ALKYLINDOLYLIDENE AND N-ALKYLBENZOTHIAZOLYLIDENE ALKANONES AS SENSITIZERS FOR PHOTOPOLYMER COMPOSITIONS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1986-12-30 | — | — | EP | disclosed |
| US-4454218-A | WITH UNSATURATED COMPOUND AND PHOTOINITIATOR | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-06-12 | — | — | US | disclosed |
| EP-0103294-A1 | N-alkylindolylidene and N-alkylbenzothiazolylidene alkanones as sensitizers for photopolymer compositions | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-03-21 | — | — | EP | disclosed |