Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 9/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | HPGD | P15428 | 2/20 | 0.69 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.57 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10892490 | 0.83 | MCL1 (0.73) | MCL1KDM4EALDH1A1HPGDPIK3CD | |
| SCHEMBL5397726 | 0.82 | MCL1 (1.00) | MCL1KDM4EALDH1A1HPGDPIK3CD | |
| SCHEMBL11163965 | 0.82 | MCL1 (0.69) | MCL1KDM4EALDH1A1HPGDPIK3CD | |
| SCHEMBL11165512 | 0.82 | KDM4E (1.00) | MCL1KDM4EALDH1A1HPGDPIK3CD | |
| SCHEMBL11162632 | 0.82 | MCL1 (0.69) | MCL1KDM4EALDH1A1HPGDPIK3CD | |
| SCHEMBL10888436 | 0.82 | MCL1 (0.69) | MCL1KDM4EALDH1A1HPGDPIK3CD | |
| SCHEMBL10888266 | 0.80 | MCL1 (0.65) | MCL1KDM4EALDH1A1HPGDPIK3CD | |
| SCHEMBL10886522 | 0.79 | MCL1 (0.60) | MCL1KDM4EALDH1A1HPGDPIK3CD | |
| SCHEMBL10886965 | 0.78 | KDM4E (0.64) | MCL1KDM4EALDH1A1HPGDPIK3CD | |
| SCHEMBL11163920 | 0.78 | KDM4E (0.64) | MCL1KDM4EALDH1A1HPGDPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4599423-A | Preparation of 5-(hydroxy- and/or aminophenyl-6-lower-alkyl)-2(1H)-pyridinones | STERLING DRUG INC. (US) | 1986-07-08 | — | — | US | disclosed |
| US-4559352-A | 1,2-Dihydro-2-oxo-5-(hydroxy-and/or amino-phenyl)-nicotinonitriles and cardiotonic use thereof | STERLING DRUG INC. (US) | 1985-12-17 | — | — | US | disclosed |
| US-4515797-A | 3-Amino-5-(hydroxy- and/or aminophenyl)-6-(lower-alkyl)-2(1H)-pyridinones and cardiotonic use thereof | STERLING DRUG INC. (US) | 1985-05-07 | — | — | US | disclosed |
| US-4465686-A | 5-(Hydroxy- and/or amino-phenyl)-6-(lower-alkyl)-2-(1H)-pyridinones, their cardiotonic use and preparation | STERLING DRUG INC. (US) | 1984-08-14 | — | — | US | disclosed |
| EP-0061774-A2 | 3-Amino-5-(substituted)-2 (1H) pyridinones and 3-cyano compounds useful as cardiotonics and preparation thereof | STERLING DRUG INC. (US) | 1982-10-06 | — | — | EP | disclosed |