Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 9/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 9/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.45 |
| ▸ | RARA | P10276 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10895093 | 0.97 | KDM4E (0.54) | MAPTKDM4EALDH1A1HPGDL3MBTL1 | |
| SCHEMBL10894272 | 0.96 | KDM4E (0.56) | MAPTKDM4EALDH1A1HPGDL3MBTL1 | |
| SCHEMBL10895077 | 0.96 | KDM4E (0.56) | MAPTKDM4EALDH1A1HPGDL3MBTL1 | |
| SCHEMBL10896425 | 0.94 | MAPT (0.46) | MAPTKDM4EALDH1A1HPGDL3MBTL1 | |
| SCHEMBL10930112 | 0.90 | KDM4E (0.45) | MAPTKDM4EALDH1A1HPGDL3MBTL1 | |
| SCHEMBL10945415 | 0.88 | KDM4E (0.43) | MAPTKDM4EALDH1A1HPGDL3MBTL1 | |
| SCHEMBL10929232 | 0.88 | KDM4E (0.49) | MAPTKDM4EALDH1A1HPGDL3MBTL1 | |
| SCHEMBL10896476 | 0.88 | CYP11B1 (0.47) | MAPTKDM4EALDH1A1HPGDCYP11B1 | |
| SCHEMBL10929260 | 0.87 | KDM4E (0.51) | MAPTKDM4EALDH1A1HPGDL3MBTL1 | |
| SCHEMBL10930409 | 0.87 | KDM4E (0.51) | MAPTKDM4EALDH1A1HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0090183-B1 | POLYHALOGENATED AROMATIC COMPOUNDS | MERCK PATENT GmbH (DE) | 1986-02-19 | — | — | EP | disclosed |
| US-4551264-A | Polyhalogenoaromatic compounds for liquid crystal compositions | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1985-11-05 | — | — | US | disclosed |
| EP-0090183-A1 | Polyhalogenated aromatic compounds | MERCK PATENT GmbH (DE) | 1983-10-05 | — | — | EP | disclosed |