Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10904413 | 1.00 | MAPT (0.43) | MAPTHCAR2NPSR1ALDH1A1NR1I2 | |
| SCHEMBL10905527 | 0.78 | HCAR2 (0.40) | HCAR2ALDH1A1LMNATSHR | |
| SCHEMBL10905645 | 0.78 | HCAR2 (0.40) | HCAR2ALDH1A1LMNATSHR | |
| SCHEMBL127082 | 0.78 | — | — | |
| SCHEMBL1260685 | 0.77 | CYP1A2 (0.47) | MAPTHCAR2NPSR1ALDH1A1NR1I2 | |
| SCHEMBL8428901 | 0.77 | HCAR2 (0.48) | MAPTHCAR2NPSR1ALDH1A1HSD17B10 | |
| SCHEMBL4937283 | 0.76 | MAPT (0.73) | MAPTHCAR2NPSR1ALDH1A1NR1I2 | |
| SCHEMBL4937290 | 0.76 | MAPT (0.73) | MAPTHCAR2NPSR1ALDH1A1NR1I2 | |
| SCHEMBL4937473 | 0.76 | MAPT (0.68) | MAPTHCAR2NPSR1ALDH1A1NR1I2 | |
| SCHEMBL4937475 | 0.76 | MAPT (0.68) | MAPTHCAR2NPSR1ALDH1A1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4590291-A | Thrombin inhibitory new dihydroxybenzene ether derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1986-05-20 | — | — | US | disclosed |
| EP-0068250-A1 | Dioxybenzene ether derivatives, pharmaceutical compositions containing them, process for the preparation thereof and their use | BAYER AG (DE) | 1983-01-05 | — | — | EP | disclosed |