Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7488263 | 0.98 | ACE (0.36) | ACESMN1; SMN2L3MBTL1CYP3A4TSHR | |
| SCHEMBL7488258 | 0.98 | ACE (0.36) | ACESMN1; SMN2L3MBTL1CYP3A4TSHR | |
| SCHEMBL10909099 | 0.97 | ACE (0.36) | ACESMN1; SMN2L3MBTL1CYP3A4TSHR | |
| Hydrochloric Acid SCHEMBL10907399 | 0.97 | ACE (0.36) | ACESMN1; SMN2L3MBTL1CYP3A4TSHR | |
| Hydrochloric Acid SCHEMBL10907401 | 0.97 | ACE (0.36) | ACESMN1; SMN2L3MBTL1CYP3A4TSHR | |
| SCHEMBL7431415 | 0.94 | ACE (0.37) | ACESMN1; SMN2L3MBTL1CYP3A4TSHR | |
| SCHEMBL7350198 | 0.92 | ACE (0.36) | ACESMN1; SMN2L3MBTL1CYP3A4TSHR | |
| SCHEMBL10600817 | 0.92 | ACE (0.36) | ACESMN1; SMN2L3MBTL1CYP3A4TSHR | |
| SCHEMBL7350203 | 0.92 | ACE (0.36) | ACESMN1; SMN2L3MBTL1CYP3A4TSHR | |
| SCHEMBL10909102 | 0.85 | CYP3A4 (0.33) | CYP3A4TSHRTDP1MAPTAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4575503-A | ANGIOTENSIN CONVERTING ENZYME INHIBITOR, HYPOTENSIVE | CIBA-GEIGY CORPORATION (US) | 1986-03-11 | — | — | US | disclosed |
| US-4473575-A | ANGIOTENSIN INHIBITORS, HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1984-09-25 | — | — | US | disclosed |
| US-4410520-A | ANGIOTENSION CONVERTING ENZYME INGIBITOR, HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1983-10-18 | — | — | US | disclosed |