Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.47 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.47 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
| ▸ | TOP1 | P11387 | 9/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10911704 | 0.90 | HSD17B10 (0.39) | PIM1CDK2FLT4CSNK2A1PRKCD | |
| SCHEMBL10914126 | 0.88 | PIM3 (0.46) | PIM1MAPKAPK3TOP1HSD17B10KDM4E | |
| SCHEMBL10938843 | 0.80 | HPGD (0.51) | HSD17B10KDM4EHPGDMEN1KMT2A | |
| SCHEMBL10913914 | 0.74 | HPGD (0.41) | HSD17B10KDM4EHPGDMEN1KMT2A | |
| SCHEMBL9432318 | 0.72 | TOP1 (0.53) | PIM1MAPKAPK3TOP1HSD17B10KDM4E | |
| SCHEMBL9432313 | 0.72 | TOP1 (0.53) | PIM1MAPKAPK3TOP1HSD17B10KDM4E | |
| SCHEMBL11112760 | 0.71 | KCNH2 (0.41) | PIM1CDK2FLT4CSNK2A1PRKCD | |
| SCHEMBL10912987 | 0.70 | MAPKAPK3 (0.36) | PIM1CDK2FLT4CSNK2A1PRKCD | |
| SCHEMBL10911903 | 0.70 | MAPKAPK3 (0.36) | PIM1CDK2FLT4CSNK2A1PRKCD | |
| SCHEMBL10859996 | 0.69 | KCNH2 (0.53) | PIM1CDK2FLT4CSNK2A1PRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0169710-A2 | 7-Substituted-6-fluoro-8-substituted-1,4-dihydro-1-methylamino-4-oxo-3-quinolinecarboxylic acids; 7-substituted-6-fluoro-1,4-dihydro-1-methylamino-4-oxo-3-naphthyridine carboxylic acids; derivatives thereof; and processes for producing the compounds | WARNER-LAMBERT COMPANY (US) | 1986-01-29 | — | — | EP | disclosed |