Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.45 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.45 |
| ▸ | NQO1 | P15559 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10501981 | 0.93 | TOP2A (0.47) | TOP2ATOP2BNQO1POLBKMT2A | |
| SCHEMBL10502602 | 0.88 | NQO1 (0.50) | TOP2ATOP2BNQO1POLBKMT2A | |
| SCHEMBL10501647 | 0.87 | POLB (0.44) | TOP2ATOP2BNQO1POLBKMT2A | |
| SCHEMBL10502223 | 0.84 | TOP2A (0.46) | TOP2ATOP2BPOLBKMT2ANPC1 | |
| SCHEMBL10502272 | 0.82 | NQO1 (0.52) | TOP2ATOP2BNQO1POLBKMT2A | |
| SCHEMBL10501071 | 0.80 | TOP2A (0.45) | TOP2ATOP2BNQO1POLBKMT2A | |
| SCHEMBL10502230 | 0.80 | NQO1 (0.51) | TOP2ATOP2BNQO1POLBKMT2A | |
| SCHEMBL10501030 | 0.79 | TOP2A (0.47) | TOP2ATOP2BNQO1POLBKMT2A | |
| SCHEMBL10925940 | 0.79 | TOP2A (0.65) | TOP2ATOP2BNQO1POLBKMT2A | |
| SCHEMBL10503399 | 0.79 | TOP2A (0.44) | TOP2ATOP2BNQO1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4604390-A | FUNGICIDES, ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY (US) | 1986-08-05 | — | — | US | disclosed |
| EP-0172632-A1 | Benzopyrano[4,3,2-cd]indazole compounds, processes for their production and pharmaceutical compositions comprising the compounds | WARNER-LAMBERT COMPANY (US) | 1986-02-26 | — | — | EP | disclosed |