Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 6/20 | 0.38 |
| ▸ | RXRA | P19793 | 3/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | RARG | P13631 | 5/20 | 0.32 |
| ▸ | RARA | P10276 | 4/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10920163 | 1.00 | RARB (0.38) | RARBRXRARXRBRXRGRARG | |
| Bromide SCHEMBL10925147 | 0.81 | — | — | |
| Bromide SCHEMBL10925139 | 0.81 | — | — | |
| Bromide SCHEMBL10925150 | 0.81 | — | — | |
| Bromide SCHEMBL10925134 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL8419044 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL10920871 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL10925045 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL8328381 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL8419046 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4544770-A | OF UNSATURATED PHOSPHONIUM COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 1985-10-01 | — | — | US | disclosed |