Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | FFAR2 | O15552 | 11/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10920568 | 1.00 | ACE (0.74) | ACELMNAFFAR2ALDH1A1POLB | |
| SCHEMBL11282508 | 1.00 | ACE (0.74) | ACELMNAFFAR2ALDH1A1POLB | |
| SCHEMBL8398559 | 0.91 | ACE (0.80) | ACELMNAFFAR2ALDH1A1POLB | |
| SCHEMBL10924084 | 0.87 | ACE (0.74) | ACELMNAFFAR2ALDH1A1POLB | |
| SCHEMBL11063036 | 0.87 | ACE (0.82) | ACELMNAFFAR2ALDH1A1POLB | |
| SCHEMBL10924088 | 0.87 | ACE (0.74) | ACELMNAFFAR2ALDH1A1POLB | |
| SCHEMBL8870553 | 0.86 | ACE (0.56) | ACELMNAFFAR2ALDH1A1POLB | |
| SCHEMBL8860652 | 0.86 | ACE (0.56) | ACELMNAFFAR2ALDH1A1POLB | |
| SCHEMBL11004289 | 0.86 | ACE (0.80) | ACELMNAFFAR2ALDH1A1POLB | |
| SCHEMBL10944184 | 0.86 | ACE (0.80) | ACELMNAFFAR2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0059966-B1 | SUBSTITUTED THIAZOLIDINE CARBOXYLIC ACID ANALOGS AND DERIVATIVES AS ANTIHYPERTENSIVES | MERCK & CO. INC. (US) | 1986-08-13 | — | — | EP | disclosed |
| EP-0059966-A1 | Substituted thiazolidine carboxylic acid analogs and derivatives as antihypertensives | MERCK & CO. INC. (US) | 1982-09-15 | — | — | EP | disclosed |