Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | TSHR | P16473 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | HTR1A | P08908 | 2/20 | 0.66 |
| ▸ | PKM | P14618 | 2/20 | 0.66 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | THPO | P40225 | 1/20 | 0.66 |
| ▸ | HTR2A | P28223 | 7/20 | 0.51 |
| ▸ | HTR7 | P34969 | 5/20 | 0.51 |
| ▸ | HTR6 | P50406 | 5/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10925192 | 0.86 | HTR2C (0.64) | HTR2CCYP2D6KDM4ECYP3A4MAPT | |
| SCHEMBL10922904 | 0.83 | HTR2C (0.64) | HTR2CCYP2D6KDM4ECYP3A4MAPT | |
| SCHEMBL10922449 | 0.83 | HTR2C (0.59) | HTR2CCYP2D6KDM4ECYP3A4MAPT | |
| SCHEMBL10920489 | 0.81 | HTR2C (0.64) | HTR2CCYP2D6KDM4ECYP3A4MAPT | |
| Setoperone SCHEMBL122185 | 0.79 | HTR2C (0.64) | HTR2CCYP2D6KDM4ECYP3A4MAPT | |
| SCHEMBL10919317 | 0.79 | HTR2C (0.73) | HTR2CCYP2D6KDM4ECYP3A4MAPT | |
| Pirenperone SCHEMBL467209 | 0.79 | HTR2C (1.00) | HTR2CCYP2D6KDM4ECYP3A4MAPT | |
| Pirenperone SCHEMBL10965711 | 0.79 | HTR2C (0.98) | HTR2CCYP2D6KDM4ECYP3A4MAPT | |
| SCHEMBL10925153 | 0.78 | HTR2C (0.62) | HTR2CCYP2D6KDM4ECYP3A4MAPT | |
| SCHEMBL22738408 | 0.78 | HTR2C (0.62) | HTR2CCYP2D6KDM4ECYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0070053-B1 | NOVEL BICYCLIC PYRIMIDIN-5-ONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-04-16 | — | — | EP | disclosed |
| US-4548938-A | PSYCHOTROPIC AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-10-22 | — | — | US | disclosed |
| US-4443451-A | PSYCHOTROPIC, ANTIHISTAMINES, ANTISEROTONINE | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-04-17 | — | — | US | disclosed |
| EP-0070053-A2 | Novel bicyclic pyrimidin-5-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-01-19 | — | — | EP | disclosed |