Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | KDM5A | P29375 | 2/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 2/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.42 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HNF4A | P41235 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10941367 | 0.82 | HPGD (0.42) | HCAR2GAARAB9AKMT2ADAO | |
| SCHEMBL7190682 | 0.81 | ERCC5 (0.53) | GAARAB9AKMT2ALMNAMEN1 | |
| SCHEMBL4671116 | 0.80 | HCAR2 (0.39) | HCAR2GAARAB9AKDM5AKDM4C | |
| SCHEMBL4671120 | 0.80 | HCAR2 (0.39) | HCAR2GAARAB9AKDM5AKDM4C | |
| SCHEMBL14604111 | 0.78 | GAA (0.45) | GAARAB9ANOTUMKMT2ADAO | |
| SCHEMBL6613866 | 0.76 | SMN1; SMN2 (0.57) | HCAR2KDM5AKDM4CKDM5BKMT2A | |
| SCHEMBL1584769 | 0.74 | DAO (0.53) | HCAR2KMT2ADAOMEN1 | |
| SCHEMBL25352675 | 0.73 | NOTUM (0.52) | HCAR2GAARAB9ANOTUMLMNA | |
| SCHEMBL5158296 | 0.73 | NOTUM (0.52) | GAARAB9ANOTUMDAOLMNA | |
| SCHEMBL27657375 | 0.73 | NOTUM (0.52) | GAARAB9ANOTUMDAOTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |