Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10942950 | 0.90 | SMN1; SMN2 (0.57) | TSHRALDH1A1SLC6A3SMN1; SMN2KDM4E | |
| SCHEMBL10940863 | 0.84 | TDP1 (0.58) | ALDH1A1SMN1; SMN2KDM4EPOLBNR4A2 | |
| SCHEMBL28000 | 0.83 | TSHR (0.63) | TSHRALDH1A1SLC6A3KDM4EPOLB | |
| SCHEMBL27840685 | 0.83 | TSHR (0.63) | TSHRALDH1A1SLC6A3KDM4EPOLB | |
| SCHEMBL29363206 | 0.83 | TSHR (0.63) | TSHRALDH1A1SLC6A3KDM4EPOLB | |
| SCHEMBL10939874 | 0.83 | SMN1; SMN2 (0.60) | ALDH1A1SMN1; SMN2KDM4EPOLBNR4A2 | |
| Benzophenone SCHEMBL29531226 | 0.81 | TSHR (0.61) | TSHRALDH1A1SLC6A3KDM4EPOLB | |
| Water SCHEMBL27735757 | 0.81 | TSHR (0.61) | TSHRALDH1A1SLC6A3KDM4EPOLB | |
| SCHEMBL10938217 | 0.81 | POLB (0.47) | SLC6A3POLBNR4A2LMNAMAPT | |
| SCHEMBL69740 | 0.80 | NR4A2 (0.48) | TSHRALDH1A1KDM4EPOLBATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |